The disagreement observed between Mn-SOD protein content and its activity in the AO adults is intriguing and suggests that Mn-SOD activity may be modulated by post-translational modification [66].
Moreover, the transcriptional effect of NF-Y can be modulated by post-translational modifications.
ACE activity, and its proposed conversion of Aβ, has been shown previously to be modulated by post-translational modification [ 30].
In response to DNA damage, WRN can be modulated by post-translational modifications, including phosphorylation, sumoylation, and acetylation.
Notably, the activity of MLL can be modulated by post-translational modifications, such as phosphorylation, ubiquitination, and proteolysis.
Thus, these data suggest that in addition to epigenetic HDAC1-dependent repression of the CerS1 promoter, CerS1 transcription might also be modulated by post-transcriptional mechanisms.
The interaction of IDRs with target proteins and DNA can be modulated by post-translational modifications, including phosphorylation, acetylation, methylation, sumoylation, and ubiquitination.
The interaction of MBP and Fyn, which would tether the latter to the oligodendrocyte membrane [ 9], could be modulated by post-translational modifications in the proline-rich region of MBP, especially phosphorylation at T92 and T95.
Regulation by WT1 is not well-defined, and its function may be modulated by post-translational modification [ 49, 50] or by physical contact with other regulators, including possible dimerization with other proteins or with itself [ 51- 58].
For example, object recognition memory consolidation and retrieval in an open field have been shown to be modulated by post-training administration of the stress hormone, corticosterone, but only when the rats were not previously habituated to the arena [63].
Differences in hnRNP K localisation appear to be modulated by post-translational modificiation, phosphorylation of hnRNP K by mitogen-activated protein kinase (MAPK) results in cytoplasmic localisation of hnRNP K. Serum stimulation is necessary for MAPK phosphorylation of hnRNP K which is indicative of cellular growth (Habelhah et al, 2001).
