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This is probably an oversimplified view, because [tCho] can be modulated by numerous changes in enzymatic activity and fluxes in biosynthetic and catabolic pathways in which choline compounds serve as both precursors and catabolites.
Several observations indicate that the presence of the DAT in the cell membrane can be modulated by numerous signaling cascades that result in phosphorylation and glycosylation and that trafficking can occur within the time frame of the HCRT manipulations discussed herein.
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This article reviews the intricate pathways that have been uncovered in which IL-12 production is modulated by numerous pathogens and immunological regulators.
It is important to recognise that the effect of age is modulated by numerous other prognostic factors such as performance status, presence of various co-morbidities, and most importantly, cytogenetics.
Additionally, IGF2 expression is modulated by numerous other factors including parathyroid hormone (PTH), cortisol, and transforming growth factor beta (TGF-β) [ 42].
Since endocytosis is modulated by numerous environmental and physiological inputs, its role in environmental tuning of signaling may extend beyond temperature compensation.
Numerous exchange reactions for metabolites known to be modulated by the gut microbiota, such as amino acids, fatty acids and energy metabolites, were found to change in flux between the germfree and microbe-associated model simulations.
Because Syk is an upstream kinase within several signaling cascades, there are numerous opportunities for serine/threonine phosphorylation events that can be modulated by its kinase activity.
This architecture can be modulated by environmental conditions, particularly in the horticulture context in which the possibilities to control growing conditions are numerous.
The rate of infrastructure replacement, thus economic activity, can be modulated by how fast the carbon tax rate increases.
Most of the synapses, however, mature after birth, giving ample opportunity for the connections to be modulated by experience.
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