Sentence examples for be modulated by mutation from inspiring English sources

The nuclease activity can be modulated by mutation of the ATP-binding cleft of the helicase domain, and is inhibited by ATP or ADP, suggesting a modified role for the inactive helicase domain in the control of the nuclease activity.

P450s may be especially prone to this type of change, since their catalytic mechanism involves large substrate-induced conformational shifts [ 40] that can be modulated by mutations distant from the active site [ 32, 37, 41].

The exonuclease activity is modulated by mutation of the helicase ATP-binding cleft and by ATP or ADP binding, suggesting a modified role for the helicase domain in the regulation of nuclease activity in these enzymes.

It has also been shown that the propensity of ApoAI to form fibrils is modulated by mutations and oxidation.

In the case of CRC, DUSP4 expression appears to be modulated by KRAS mutations [ 38- 40].

This is supported by the fact that the interaction affinity could be modulated by the mutations in CPXacc.

These findings indicate that the propensity to form filaments can be modulated by specific mutations in Gln1.

The finding that the chaperone function could be modulated by point mutations of specific arginine residues enabled us to undertake this study.

Furthermore, it is clear that the effect of specific mutations may be modulated by other missense mutations in cis (32, 33).

Many other features, related to the multitude of roles and interactions of thioredoxin in vivo, may be expected to be modulated by high-frequency mutations.

However, the digenism described in animal models for HPE supports the existence of a heterogeneous and multigenic mechanism in some human cases, in which the penetrance and expressivity of heterozygous loss-of-function mutations can be modulated by one or more other mutations (Mercier et al., 2011; Roessler et al., 2012).