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The paired-pulse measures taken here reflect the activity of particular cortical interneuron pools whose activity may be modulated by exercise, but which are only one of a multitude of inputs on the descending motor neuron.
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Using our microarray dataset [ 8], we selected ECM factors that (a) demonstrated evidence of being modulated by exercise training and (b) were relevant for ECM remodeling [ 32- 34].
Finally, three genes unrelated to ECM biology but previously described as being modulated by exercise [ 8], interleukin 17D, Rho-GTPase-activating-protein 1 and myristoylated alanine-rich protein kinase C substrate, did not significantly vary in their expression between HRG and LRG (data not shown).
The initiation of apoptosis is dependent on a variety of signals, many of which can be modulated by strenuous exercise [ 4- 7].
7,9,10 Intriguingly, the amount of new neurons eventually added to the network as well as their synaptic maturation can be modulated by experience (i.e. paradigms like voluntary exercise or EE).
Fiber-type composition can be modulated by a number of different factors such as exercise, aging, or hormonal changes (Wu et al., 2003).
Furthermore, since skeletal muscle increased levels of oxidative damage with aging [ 28, 29], regular exercise is very useful in increase its antioxidant potential that can be modulated by the activity of SIRT1 [ 28- 31].
The rate of infrastructure replacement, thus economic activity, can be modulated by how fast the carbon tax rate increases.
Most of the synapses, however, mature after birth, giving ample opportunity for the connections to be modulated by experience.
These processes could be modulated by HS.
The pulse amplitude is known to be modulated by respiration.
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