Sentence examples for be modulated by epigenetic from inspiring English sources

Besides genetic variation, gene expression can be modulated by epigenetic factors.

Our data add more weight to the notion that the activities of 'housekeeping' transcripts and their products might be modulated by epigenetic means.

The range of cognitive outcomes could be modulated by epigenetic modifications that occur in response to environmental influences and affect gene transcription in cognitively relevant brain regions.

Gene transcription may be modulated by epigenetic modifications which involved different reactions such as methylation of DNA and phosphorylation, sumoylation, ubiquitination, or acetylation of histone proteins (Huber et al. 2007a).

It will also provide an invaluable opportunity to further examine whether associations between a variety of early growth and nutritional exposures and later phenotype, may be modulated by epigenetic mechanisms.

In the case of chronic lymphocytic leukemia (CLL) a number of genes are reportedly silenced by epigenetic alterations including the wnt pathway inhibitor genes [ 5, 6] and more recently micro RNA expression was found to be modulated by epigenetic changes [ 19].

Nevertheless, there is value in speculating why LUCA may have had a dynamic genome whose inheritance was modulated by epigenetic phenomena.

The length of the initiation phase influences the size and duration of a transcription burst and is modulated by epigenetic changes of the involved chromatin regions.

Adult neurogenesis is a highly plastic process, which can be enhanced by environmental stimulation and physical exercise (Kempermann et al., 1997; van Praag et al., 1999) and it is modulated by epigenetic mechanisms, microRNAs (Cheng et al., 2009; Yoo et al., 2009; Ma et al., 2010), and growth factors.

This step can also be modulated by regulation of DNA repair and epigenetic modifications to DNA by micro-RNAs, and the converse regulation of micro-RNAs by these mechanisms, as has been highlighted in cancers with micro-satellite instability [ 45].

Since multiple single-nucleotide polymorphisms (SNPs) associated with poor activity to clopidogrel [ 11] did not appear to directly affect P2Y12 expression, the altered expression of P2Y12 was likely to be modulated by methylations of promoters or other epigenetic changes.