Moreover, Notch signaling which can be modulated by cell-associated and soluble ligands has been shown to be crucial for the maintenance of satellite cell quiescence 47, 48.
An exciting aspect of the Hippo pathway is that its growth-regulating activity can be modulated by cell-surface proteins that are capable of binding to ligands expressed on adjacent cells.
If such covalent modifications occur, however, it is difficult to envision how they are modulated by cell signaling.
The phosphorylation of paxillin is modulated by cell adhesion.
The amount of AhR that is present in the nuclear and cytoplasmic compartments of the cell is modulated by cell density in keratinocytes [ 31] and hamster fibroblasts [ 5].
Moreover, the finding that the protein composition of EVs was modulated by cell stimulation indicates that packing of mediators within EVs is a regulated process.
Pancreatic beta cell mass expansion is a normal response to an increased demand for insulin, as occurs when mice are fed a HFD, total beta cell mass being modulated by cell proliferation and/or apoptosis (Ackermann & Gannon, 2007; Sachdeva & Stoffers, 2009).
Our recent study of basonuclin suggests that rRNA transcription is modulated by cell-type-specific factors [23] [25].
Furthermore, the expression of all MMP inhibitors was modulated by cell-Matrigel contact only in highly invasive and metastatic cell lines.
