Sentence examples for be modulated by binding from inspiring English sources
Slow inactivated states in voltage-gated ion channels can be modulated by binding molecules both to the outside and to the inside of the pore.
It should be emphasized that although the Gli mRNA levels may be modulated by binding events at the Smo receptor, it is impossible to rule out additional interactions with downstream pathway components, so interpretations should be made cautiously.
Cisplatin binding has been observed in vitro within rRNA, tRNA, siRNA, and miRNA, but it is not known to what extent these RNAs are targeted in cellular conditions, where accessibility may be modulated by binding partners and Pt concentrations mediated by other factors.
More recently it has been found that the CUL4-DDB1 canplex can be modulated by binding of the drug, lenalidomide leading to degradation of lymphoid transcription factors IKZF1 and IKF3 in multiple myeloma cells (Fischer et al., 2014; Kronke et al., 2014).
A remarkable feature of the structure is a large internal cavity with a volume of 550 Å3 suggesting that the activity of HlyIIR is modulated by binding of a ligand, which triggers the toxin production.
These features can be utilised in the construction of biosensors for a wide range of target compounds as, in principle, any regulatory protein whose activity is modulated by binding to a small molecule can have its effector/inducer profile artificially altered.
Its bioactivity is modulated by binding to IGF-binding proteins (IGFBPs) present in serum and tissues.
Ubp3 function is modulated by binding cofactor Bre5 (Li et al, 2005, 2007).
Importantly, these data demonstrate that the oligomeric state of NEMO is modulated by binding of specific ligands.
The equilibrium between the apo-caspase (inactive) and the mature caspase is modulated by binding of substrate in the active site or by binding of inhibitors in allosteric sites.
Second, many key cytoplasmic enzymes are modulated by binding long-chain acyl CoA (Faergeman and Knudsen, 1997), a CoA metabolite that will be generated immediately if CoA is released (Idell-Wenger et al., 1978).
