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These interactions can be modulated by additional interactions with residues adjacent to the turn at positions i + 4 and i + 6.
The threshold for infarction may also be modulated by additional factors, such as changes in glucose metabolism leading to an increase of lactate, the influx of Ca2+ ions into the cell and the release of excitatory amino acids [7].
Substrate specificities of E3s are thought to be an intrinsic property of these enzymes, but whether it can be modulated by additional factors is an open question.
This can be modulated by additional Gli TFs expressed in the CMZ (data not shown) as reported in fish and frog, regulating rx2 expression via the same evolutionarily conserved motif.
Several of the components identified in glioma ECMs are permissive substrates enhancing cell migration, but like the interaction of MGP and vitronectin, effects can be modulated by additional ligands or modifications.
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In the nanoribbons, the electronic properties are further modulated by additional confinement and possible edge functionalization [8, 9].
These observations suggest that HCN subunits are modulated by additional β-subunits and regulatory proteins in native tissue.
The finding of no or extremely low LCAT activity in affected patients suggests that expression of the disease is modulated by additional environmental factors and genes of minor importance [ 79, 80].
This fact could be modulated by the inclusion of additional adjuvants such as TLR9 agonists.
The efficacy of the OK107 > unf-induced lethality may also be modulated by the presence of additional UAS elements.
These data suggest that FRs may be modulated by gap junctions, although additional experiments in vivo will be necessary to determine the precise role of gap junctions in this pathological activity associated with epileptogenesis.
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