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These results also underscore the importance of tight regulation of the IP3 signaling cascade, and demonstrate how IP3 signaling can be modulated at multiple inputs in the pathway.
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As the NF- κB response is modulated at multiple levels (e.g., cytokine receptor desensitization, cooperative transcriptional regulation, etc).
The use of photon pulses is equivalent (via Fourier transformation) to measurements with light that is modulated at multiple frequencies (practically up to 1 GHz).
ATF4 transcriptional activity is modulated at multiple levels, including transcription and translation, post-translational modification and repression of its transcriptional activity through protein interactions (7, 8, 23, 49– 51).
25HC was reported to inhibit virus-cell fusion through direct alteration of cellular membrane composition (Liu et al., 2013), although it is also possible that viral infection is modulated at multiple post-entry events (Schoggins and Randall, 2013).
This process is mediated by a multi-component machinery [reviewed in Chacinska et al., 2009; Dolezal et al., 2006; Fox, 2012; Harbauer et al., 2014; see also Fig. 1 and its legend], the activity of which is modulated at multiple levels to regulate biogenesis, composition and turnover of the organelle in connection with cellular metabolism, signaling and stress (Harbauer et al., 2014).
The bell can be modulated at the will of the subscriber.
HIF-1 α could be modulated at several levels 1.
Source light is modulated at 110 MHz resulting in detected AC, DC and Phase information from multiple distances.
Wnt-signalling is modulated at several levels.
A checkerboard stimulus was modulated at two reversals per second.
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