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LPS-stimulated MT-null Mϕ produced less NO than those of control mice.
MT-null Mϕ produced less NO in response to TNF-alpha stimulation.
Control Mϕ had a bactericidal effect on Staphylococcus aureus, but MT-null Mϕ had significantly lower activity.
The rate of conversion of [14C]-l-arginine to citrulline, which is formed with NO by the action of iNOS, was much lower in MT-null Mϕ than in control cells.
No notable changes were found in arginine uptake or in expression of cationic amino acid transporter 2 (a major arginine transporter in Mϕ) between control and MT-null Mϕ.
The MT-null mice show low concentration of Zn in skin, and the epidermis fails to exhibit hyperplasia [22].
The age-dependent expressions of MT isoforms might be modified in MT-null mice.
These effects of MeHg appeared exaggerated in the MT-null strain.
Second, would the MT-null strain be affected more than its parent C57BL strain?
This emergent toxicity was exaggerated in MT-null mice and was more distinct in females.
In addition MT-transgenic animals are more resistant, whereas MT-null mice are more sensitive than controls to Cd-induced lethality and hepatotoxicity.
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