We expect that this format will be modified further as requirements for the Virtual Patient cases develop and expand.
After rebuilding of the structure, it was concluded that fatigue had occurred, being caused by wind-induced vibration, and the structure had to be modified further to provide direct support for the cantilevered portion of the structure that had collapsed.
These could be modified further to express antigens of interest, for example non-binding factor H binding mutants, plus other targets to cover invasive disease caused by Nm strains that do not express fHbp, which has been one of the major vaccine antigens considered over the last few years (Lucidarme et al., 2011).
They can also be modified further.
Before proceeding further with our study, the GCT was modified further to address items still problematic for the reviewers.
The new CocE mutant (i.e. the T172R/G173Q/L196C/I301C mutant of CocE, denoted as enzyme E196 301 for convenience) was modified further via PEGylation in order to extend the in vivo residence time of the enzyme.
In addition, the UniProtKB database for BLAST searches has not been modified further and sequence redundancy has not been reduced.
This sum is usually modified further, for example, by adjusting the activation sum to a value between 0 and 1 and/or by setting the activation to zero unless a threshold level for the sum is reached.
The materials prepared in this paper can be modified for further development in various applications.
Therefore, here we present a methodology to rapidly create systems that can be quickly designed and fabricated, utilized as needed, and then whose constituent components can be modified for further experimentation or incorporated into future systems.
