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During the past decade a substantial number of autoantigens have been shown to be modified during apoptosis and/or necrosis.
As outlined, nuclear autoantigens may be modified during apoptosis and lead to maturation of dendritic cells in SLE [ 6, 11, 12].
Until now, none of the subunits of the exosome complex had been shown to be modified during apoptosis, prompting us to investigate the molecular characteristics of exosome subunits in apoptotic cells.
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Nucleosomes that are modified during apoptosis, and/or endogenous danger ligands incorporated in blebs are responsible for the maturation of mDCs, which subsequently secrete proinflammatory cytokines such as IL-6, and present apoptosis-induced, modified auto antigens in an immunogenic way to T cells.
Did the torch have to be modified during the tests?
Antibodies from these patients recognize self-antigens that are modified during the process of apoptosis.
Several of the rules were modified during the recess.
The program was modified during the follow-up when needed.
The apoptosis of BECs may be a potential source of 'neo-antigens' that are responsible for activating autoreactive lymphocytes, as many autoantigens are selectively modified during apoptosis and may facilitate molecular mimicry or autoimmunity.
Intermediate filaments, such as lamins, are also modified during apoptosis.
Here we show for the first time that one of the exosome subunits, PM/Scl-75, is specifically modified during apoptosis.
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