Sentence examples for be modified by polymorphisms from inspiring English sources

These were cloned into an expression construct lacking a vector-based promoter, so that β2AR expression was driven by its promoter, and steady state expression could be modified by polymorphisms throughout ADRB2 within a haplotype.

Nor did we find this association to be modified by polymorphisms in the ALAD gene or by medication use.

A potential effect of methyl donor intake on DNA methylation may be modified by polymorphisms in folate metabolizing enzymes.

There is increasing evidence that bone disease may be modified by polymorphisms at loci that are involved in bone metabolism, including the genes for the vitamin D receptor, collagen, and the oestrogen receptor [ 4– 7].

Recently, the effect of passive smoking on asthma phenotypes in children was also reported to be modified by polymorphisms in the β 2-adrenergic receptor (ADRB2) gene (Zhang et al. 2007), which supports previously observations in adults (Wang et al. 2001).

Because the cellular signaling of TLRs can be modified by polymorphism [ 4] and the subunits of NF-kB expression may be affected by DAA [ 5], participants in DAA clinical trials should have TLRs and NF-kB expressions as similar as possible so that groups can be appropriately compared.

Future work could study if the effect of PM on preterm birth is modified by polymorphisms in proinflammatory cytokine genes.

However, whether an influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators has not previously been studied in relation to CRC.

Case control studies suggest an association between blood lead and essential tremor, and that this association is modified by polymorphisms in the δ-aminolevulinic acid dehydrogenase (ALAD) gene.

Our goals in this study were to determine whether there are associations between primary and secondary methylation ratios and risk of skin lesions and whether these associations were modified by polymorphisms in GSTM1, GSTT1, and GSTP1.

We found that associations of the secondary pollutants, specifically OC and SO42-, with 8-OHdG, a direct oxidative stress-related biomarker, were modified by polymorphisms in genes related to oxidative defenses.