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Timing of cyclic expression may be modified by interactions among regulatory motifs or posttranscriptional mechanisms.
For example, the DNA specificity of Hox HDs is known to be modified by interactions with co-factors such as the PBC and MEIS subclasses of TALE HD proteins (Moens and Selleri, 2006; Mann et al., 2009).
STAT5A signaling in breast cancer cells can be modified by interactions with c-Myb [ 53] and Brk [ 54]. c-Myb and STAT5A associate in a PRL-inducible manner in T47D and MCF7 breast cancer cells, stimulate expression of STAT5A downstream genes, and are associated with increased PRL-induced cell proliferation.
In line with this, acidity per se is the most likely direct selective factor behind divergence in embryonic acid tolerance, whereas divergence in larval life-history traits may be modified by interactions between pond pH, predator densities and climatic conditions - or factors closely correlated with them.
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Since BAG3 is a co-chaperone of Hsp70/Hsc70 and an interacting partner of HspB8, inhibition of αB-crystallin R120G aggregation can also be modified by interaction with HspB8 or Hsp70.
The authors report that this overall finding is modified by interactions between grazing intensities, timing and amount of precipitation, all of which are similarly variable in real life pastoralist and rangeland conditions.
The movement of water molecules in the extracellular space is modified by interactions with cell membranes and macromolecules.
Since idiosyncratic adverse drug reactions are thought to be multigenic, it is likely that the risks of developing hypersensitivity are modified by interactions between multiple genes.
Various states of water, whose physical and chemical properties are modified by interactions with a solute, have been discussed and studied since the beginning of twentieth century [ 1].
As a consequence, water movement in tissues is neither entirely free nor random, being modified by interactions with hydrophobic lipid-containing cell membranes, intracellular organelles, and macromolecules and by flows within tubular channels such as blood vessels, capillaries, interconnected pores, and ducts.
We also tested whether the OS was modified by interaction between the effect of other significant clinical parameters and chemotherapy regimens given; the first-level interaction term between these variables was entered into separate multivariate model.
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