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In this study, pre-clinical experiments were set up using a human osteosarcoma model induced in athymic nude mice to determine whether tumor growth may be modified by fat grafts.
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The lack of association between measures of adiposity and the size of the IPFP might suggest that the IPFP size is not simply a marker of obesity, but may be modified by fat-free mass.
We hypothesized that the association between plasma leptin concentration and absolute mammographic density could be modified by the amount of fat tissue in the breast.
The association of total fat intake with ovarian cancer may be modified by hormone and reproductive factors such as parity and oral contraceptive use.
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Another process that is central to the development of fat is tissue remodeling, identified in both Ingenuity Pathways analyses and GSEA (fibrinolytic pathway including matrix metallo-proteases (MMPs)) to be modified by UAG.
BetaGene also showed that the association between TCF7L2 and OGTT-based insulin secretion is modified by total body fat [ 66].
Meanwhile, we also evaluated how these associations were modified by BMI, inflammatory markers, body fat mass or trunk fat percentage and other established risk factors in 1055 middle-aged Chinese men and women.
Diets were custom prepared by Research Diets Inc., based on the D12450B low-fat (10 kcal% fat) or D12492 high-fat (60 kcal% Fat) diets, and were modified by exchanging 5% of the dietary protein with egg white for a final OVA content of 1% by weight.
18 Secondly, the volume of distribution is modified by an increase in body fat, and a decline in body water and serum albumin levels.
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