The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline or follow-up adduct levels and the intraindividual variability in adduct levels are modified by endogenous and environmental factors.
The spatial/temporal regulation of genes can be modified by using appropriate endogenous regulatory elements, such as fruit-specific promoters.
Although elemental incorporation rates can be modified by exogenous and endogenous factors including temperature, growth rate and physiological status [41] [43], these effects are typically small in magnitude compared to those driven by the large gradients in dissolved ambient concentrations between fresh and marine habitats.
64 The important decrease in endogenous oestrogen levels after menopause may contribute to the development of AD. 65 Despite the protective effect of oestrogens on AD, this effect might be modified by ER polymorphisms, particularly in the APOE*ɛ4 allele carriers.
These results suggested that the effect of IL-17 on the development of pannus-like tissue was modified by IL-17-enhanced endogenous PGE2 production.
In particular, it would have been of interest to explore whether relationships with diabetes were modified by level of obesity or by endogenous hormone levels.
Endogenous SOD2 is modified by acetylation.
We also validated that endogenous RTN4 was modified by ISG15 by immunoblot, and we detected an upshifted ladder of modified RTN4 that was also recognized by the ISG15 antibody.
In line with previous observations that mammalian TPCs are glycosylated [ 2, 11], both endogenous and heterologously expressed SpTPC2 are modified by N-glycosylation; however, no N-glycosylation was detected for endogenous SpTPC3 (data not shown) or heterologously expressed SpTPC1 and SpTPC3.
To demonstrate that endogenous NACC1 proteins are modified by SUMO, we first examined HeLa and MCF-7 by IP with anti-NACC1 antibody, but no migrating band was observed (data not shown).
