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In this study one of the CT infections would be missed using a cut off score of 8.
Although common hexanucleotide indels at this locus are clinically benign, any pathogenic mutation present in cis would probably be missed using a conventional approach for variant detection.
Also apart from supercoiling, the folded nucleoid also forms tertiary structures, which might form clustered regions which might be missed using a simple mapping of genes along the chromosome.
While the specificities of the stronger epitopes were described before (18, 27 – 29), responses to peptides 42, 151, and 164 would likely be missed using a vaccine delivery weaker than the CM regimen.
However, because of the arbitrary multiple testing used in these studies, genetic variants that confer a small disease risk but are of potential biological importance are likely to be missed using a "most significant SNPs/genes" approach [ 9, 10].
We also examined one sample and ANOVA analyses for individual voxels surviving family-wise error correction at the voxel level (P < 0.05) to identify effects in small regions (e.g. the amygdala or thalamic nuclei), which might be missed using a test of significance based on the extent of activation (i.e. cluster level correction for multiple comparisons none found, thus not reported further).
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Agreement is usually higher for externalizing diagnostic categories than for internalizing ones and many authors suggest that diagnoses of anxiety and depression can be missed using an unstructured interview.
Interestingly, bilateral phasic responses were observed, which only partly overlapped with the tonic network and which would have been missed using a standard analysis.
Separating out these exposures allows the assessor to focus on combined exposures that would have been missed using a chemical-by chemical based approach.
Thus, most genes identified here would have been missed using a standard differential analysis of bulk gene expression.
The asthma case definition that was used in this study contributed to better identification of children with asthma, who would otherwise have been missed using a history of audible wheeze alone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com