Sentence examples for be methylated in normal from inspiring English sources

For all analyses, the first six CpG sites were excluded as they are known to be methylated in normal samples [12].

However, this region was also found to be methylated in normal colonic tissue and therefore is unlikely to account for the differences in SGK1 expression seen between normal and tumour tissue samples, which are instead most likely due to transcriptional repressors acting on the SGK1 promoter.

Some of these eight genes were also found to be methylated in normal ileum and/or blood samples (Table 1).

Previously, Bhatia et al [ 36] have demonstrated 14-3-3σ 14-3-3σ 14-3-3σylated in normal lymphocytes.

In the last few years it became apparent that many markers that are methylated in cancer have been shown to be methylated in normal tissues as well [ 12, 13, 56, 57].

Type A methylation sites were originally proposed to describe CpG islands that are methylated in normal tissue and whose methylation increases with age, with the best-known examples being ERα and MYOD Toyotaa et al, 1999).

This heterogeneity may confound molecular analysis, especially of LINE-1 methylation status, as LINE-1 is methylated in normal cells.

After excluding genes that were methylated in normal bronchial epithelial cell lines, the methylation state of 14 100 gene promoters defined by 200 bp 5′ of the TSS and extending through the 5′-untranslated region was determined in vehicle Calu-6 tumours.

THBS4 promoter methylation occurs in a manner representative of a Type A gene, which is methylated in normal aged colon as part of the aging process.

The best example is a gene called agouti, which is methylated in normal brown mice.

It is noteworthy that none of these genes are methylated in normal colon epithelial cells CCD841.