There were methodological differences in randomisation, blinding, allocation concealment and varying outcome measures.
These results are very similar to what has been reported in other regions of the world for this subgroup of subjects., Although there are methodological differences in subject selection, type of vitamin D assay used and study design, most of the studies from South America were done at latitudes with abundant sunlight present throughout the year.
Other likely contributors to the controversy are methodological differences, especially in relation to analysis.
12 There are methodological differences and gaps in these studies, as discussed below; however, the coherent trend across countries (the USA, 13 14 Canada, 12 the Netherlands 16 and now France) with different health systems is noteworthy.
Although there were methodological differences between studies, particularly in relation to the use of normalized cDNA libraries herein, an apparent difference in the diversity of transcripts encoding SCP/TAPS might reflect distinct roles for various types of these molecules in H. contortus compared with A. caninum during the invasion process in the host.
In addition, there were methodological differences concerning infection and cultivation procedures as well as assays used.
Our study has a similar scope to the series reported by Adhikari et al. [ 23]; however, there are important methodological differences in the HFOV protocols and the type of recruitment maneuver (that is, a slow stepwise maneuver in our study versus a sustained inflation in Adhikari et al).
Although most studies used random effects models [ 24], there are important methodological differences in the models considered that may contribute to the diversity of findings.
There were important methodological differences in these studies, including the method of subtype definition of the luminal-B subgroup (particularly the inclusion of ER-positive and HER2-positive breast cancer in some studies), and differences in chemotherapy received.
Alternatively, it may be due to methodological differences in the way in which the T-cell infiltrate was calculated.
