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Use of vegetable oil triacylglycerides as a carbon source, however, requires cleavage of the fatty acid chains from glycerol before they may be metabolized via the β-oxidation pathway.
SF and IB are passively absorbed by enterocytes, conjugated with glutathione and transported into the systemic circulation to be metabolized via the mercapturic acid pathway and excreted predominantly as N-acetylcysteine conjugates in the urine [14].
In fact, 73% of the ambient benzene dose would be metabolized via the unidentified high-affinity pathway.
SORD converts sorbitol to fructose, and the latter can then be metabolized via the glycolytic pathway to produce adenosine triphosphate (ATP).
Further, fructose may be metabolized via the pentose phosphate pathway to produce reducing equivalents, ribose sugars, and fatty acids for synthesis of lipids.
AMT is transported to tumor tissue via the large neutral amino acid transporter and can be metabolized via the immunomodulatory kynurenine pathway [ 6, 8, 12], whose activation leads to tumoral immune tolerance [ 13].
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The glucuronic acid is cleaved from the aldotetrauronic acid (2- O-α- 4- O-α- 4yl-D-glucurO-α- 4)-xylO-methyl-D-glucuronosyl -xylotriosehe actiO-methyl-D-glucuronosyl -xylotriose metabO-methyl-D-glucuronosyl -xylotriosethway, alsO-methyl-D-glucuronosyl -xylotrioseizatiO-methyl-D-glucuronosyl -xylotriose
The substance is thought to have little or no capacity as a direct acting and/or irreversible metabolism dependent inhibitor of cytochrome P450 enzymes, and thus is unlikely to reduce the metabolic clearance of substances that are metabolized via the cytochrome P450 enzyme systems.
Citrate is metabolized via the citric acid cycle, and its metabolism is oxygen-dependent [ 21– 23].
It is metabolized via the citric acid cycle and is eventually excreted by the lungs as carbon dioxide and water [23].
(II) FA is metabolized via the phenylpropanoid degradation (Phd) pathway, which yields 3,4-disubstituted benzoic acid and acetyl-CoA from phenylpropanoids such as FA and p-coumaric acid, and FA is converted into VA and acetyl-CoA (Kallscheuer et al. 2016).
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