Sentence examples for be mediated through reduction from inspiring English sources

In both treatment methods, these beneficial effects might be mediated through reduction of anaphylatoxic C5a activity and subsequent inhibition of inflammation and apoptosis pathways.

We attribute this effect to the anti-inflammatory effect of Ral that could be mediated through reduction of IL-1β, TNF-α and IL-8, all can be released by inflamed colonic cells [26].

This inhibition may be mediated through reduction in the levels of growth factors [ 34], analogous to the reduction of insulin or IGF-1, as was shown here.

These benefits, however, do not seem to be mediated through reductions in the overall duration of injecting and might be associated with prolonged duration, albeit at reduced frequency during treatment.

It has been proposed that DR lifespan extension is mediated through reduction of mTORC1 signaling, and activation of sirtuins and other NAD+-dependent mechanisms through an increase in respiration (Guarente, 2013; Johnson et al., 2013).

Our results demonstrate that the orally administered fractions of latex of C. procera are effective in attenuating yeast-induced pyrexia and this effect is mediated through reduction in the levels of PGE2.

Accordingly, the metabolic effect of gastric bypass surgery seems to be mediated through weight reduction.

Since mouse CSF-1 does not stimulate the human receptor, these data argue for the effects of the CSF-1 antisense molecules to be mediated through the reduction in TAMs (Aharinejad et al 2002).

The mechanism behind the antiproliferative effect of AN-9 appeared to be generally p21-independent, and the increased apoptosis was thought to be mediated through the reduction in the expression of antiapoptotic bcl2 gene or alternatively through the induction of genes involved in the death receptor pathway [ 85].

First, this effect might be mediated through cardiovascular risk factor reduction, partly through a dampening effect of ethanol on platelet aggregation, or through a modification of the serum lipid profile.

Studies in acute MI models have shown the beneficial functional effect of HGF therapy to be mediated through induction of angiogenesis [11], reduction of fibrosis [5], and contribution to recruitment of stem cells from the bone marrow [19] – effects associated with myocardial regeneration.