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The results exhibited significant toxicity of Ni NPs in human lung epithelial A549 cells which is likely to be mediated through oxidative stress.
Besides postprandial lipaemia, postprandial glucose is an independent predictor of diabetes and CVD, an effect which may be mediated through oxidative stress and inflammation.
Additionally, in a recent study, gliadin effects on enterocytes have been shown to be mediated through oxidative stress, NFκB activation and IL15 upregulation (9).
Detection of different level of risk within the population and greater understanding of the etiologic mechanisms may allow for the development of new prevention strategies; thus present findings suggest that neurotoxic effects of p,p′ -DDT might be mediated through oxidative stress.
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Inflammatory effects of NPs were dependent on the surface area and were mediated through oxidative stress as they were inhibited by catalase.
Several studies have suggested that part of hepatocellular injury induced by TAA is mediated through oxidative stress caused by the action of cytokines through lipid peroxidation [ 47].
In addition, prolonged hyperglycaemia is an independent risk factor for the development of microvascular and macrovascular complications of diabetes mellitus which is mediated through oxidative stress [ 55, 58].
These studies suggest that upregulation and activation of MMP-9 by proinflammatory factors are mediated through oxidative stress (ROS production) during brain injury and inflammation.
In E. coli, the protective role of VHb is mediated through oxidative stress regulator OxyR, which in turn activates VHb biosynthesis [ 19, 20].
To determine whether the ebselen induced cytotoxic effects were mediated through oxidative stress, we measured the production of ROS in cell cultures challenged with ebselen in time and concentration manners.
Of note, however, high glucose induced cellular stress has no obvious effects on other antioxidants in rat pancreatic islets or in clonal β-cell line [ 44]. β-cell apoptosis induced by long chain saturated NEFA, such as palmitic acid, is mediated through oxidative endoplasmic reticulum (ER) stress [ 45- 47].
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