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These effects may be mediated through increased CD44 clustering and the ERK/SOX-9 signaling pathway.
Some of this effect appears to be mediated through increased expression of heat shock protein 70 with glutamine administration [ 40].
Thus, chemosensitisation by BSO appeared to be mediated through increased intracellular drug concentrations and/or protein binding.
These actions may be mediated through increased nutrient metabolism, as evidenced by the increase of cellular NAD(P H levels associated with lowered pHi.
These metabolic changes may underpin the syndrome of cachexia and may in part be mediated through increased pro-inflammatory cytokine activity.
Acute hyperglycaemia is an independent cardiovascular risk factor in Type 2 diabetes which may be mediated through increased oxidative damage to plasma low density lipoprotein, and in vitro, high glucose concentrations promote proatherogenic adhesion molecule expression and matrix metalloproteinase expression.
Similar(49)
The effects on breast cancer may be mediated through increasing birth weight by birth order.
It is suggested that the influence of ginseng on increased phosphorylation of TnI may be mediated through increasing Ca2+ concentrations.
The well established effect of air pollution on cardiorespiratory mortality may not be mediated through increasing the acute risk of myocardial infarction, but through another mechanism.
Although most of the effect of viral suppression on decreasing mortality is likely to be mediated through increasing CD4+ cell count, nevertheless there remained an independent effect of detectable viral load on life expectancy.
Thus, these small interfering RNA experiments demonstrate that the increased survival seen in cells following PTEN knockdown are mediated through increased phosphorylation and activation of AKT and increased phosphorylation promoting inhibition of Bcl2-antagonist of death.
More suggestions(17)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com