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Due to its position downstream of the MC4R its influence on weight regulation is likely to be mediated through effects on MC4R expression.
Cardiac benefits conferred by ω-3 fatty acids in coronary heart disease are unlikely to be mediated through effects on these systems.
Part of the changes in plant communities may be mediated through effects on the fungal community, through reductions in mycorrhizal colonization (Lawrence et al. 2003).
It has been suggested that some aspects of air pollutant toxicity may be mediated through effects on the immune system [ 6].
Other studies have also linked abnormal arginine vasopressin levels to changes in mood and behavior [ 68], which may be mediated through effects on adrenocorticotrophic hormone and cortisol [ 69].
HSP90 and its co-chaperones modulate tumor cell apoptosis, and much of their activity seems to be mediated through effects on the PI3K/Akt pathway and NF-κB function.
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Many of the effects of fire on forest processes are mediated through effects on vegetation structure.
The dietary treatment effects found in the current study likely have been mediated through effects on body weight.
The effect of nitrogen (N) on crop growth and productivity is mediated through effects on both light interception (green crop area) and radiation use efficiency (RUE).
The extent to which the effects of physical activity are mediated through effects on adiposity also requires further investigation.
Thus, it is unlikely that the aspirin-induced increments of fibrin network permeability were mediated through effects on platelet microparticles.
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