Sentence examples for be mediated through direct from inspiring English sources

We also found that neither MC3-R protein nor mRNA was expressed in mouse kidney, suggesting that renal Gamma-MSH action may not be mediated through direct effects on tubular Na transport but rather through effects on central neural pathways that innervate the kidney.

Intercellular communication plays an essential role in multicellular organisms and can be mediated through direct cell cell contact or through the transfer of secretory molecules.

The developmental inhibition at the tight aggregate stage could be mediated through direct cell-to-cell contact, or by secretion of an inhibitory compound.

The cross-talk between tumor and stroma cells could be mediated through direct heterotypic cell-cell contacts or secreted molecules comprising growth factors, cytokines and extracellular matrix proteins.

The stimulatory effect of Ca2+ could potentially be mediated through direct interaction of Ca2+/CaM to the C-terminus of RalA [8], [30] and/or through binding of Ca2+/CaM to RalGDS with a consequent stimulation of the exchange factor function [27].

Our finding that TtPilF binds to nucleic acid suggests that this function could be mediated through direct interaction of the ATPase with DNA in the cytoplasm.

The effect of PDT is mediated through direct ablation and immune-mediated vascular stasis [ 11, 16].

The findings from this study show that the non-transformed cell types and the ECM of the bone marrow are modified early in the development of leukemia, most likely via interactions that are mediated through direct cell contact and secreted cytokines, chemokines and other factors.

It also remains unclear whether this beneficial effect is mediated through direct effects of incretin hormones on contractile function or changes in myocardial glucose delivery [8].

We do not, however, believe that any of the toxic effects of caffeine is mediated through direct generation of reactive oxygen species, since the sensitive Pap1 pathway is not induced at any concentration of the drug (we have tested caffeine concentrations ranging from 0.05 to 30 mM, and none of them activate Pap1; data not shown).

The initial lesion is mediated through direct mechanical damage at the impact site.