Sentence examples for be mediated through binding from inspiring English sources

This Aiolos and OBF-1 independent silencing pathway could be mediated through binding of Ikaros homodimers at the λ5 promoter.

The effects are thought to be mediated through binding to an intracellular receptor protein, the vitamin D receptor (VDR).

According to several studies, the anti-apoptotic function of p21 appears to be mediated through binding and inhibition of caspase-3, ASK1, JNK, p38 and CDKs.

The inhibitory effect of propofol seems not to be mediated through binding to GABAA receptors, but seems to involve enteric opioidergic pathways.

These are known to be mediated through binding of cysteinyl LTs to the cysLT receptor 1 (CysLT1), hence, antagonism of CysLT1 and inhibition of 5-LO are reported to have therapeutic potential to manage asthmatic condition [ 63].

This is in part thought to be mediated through binding of the EAF3 chromodomain-containing protein to H3K36me2 and recruitment of the HDAC-containing RPD3S co-repressor complex [ 26, 27].

Most of the known biological actions are mediated through binding to the vitamin D receptor present in almost all tissues and cells within the human body.

With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner.

To determine whether the negative regulatory effects of miR-203 on Slug expression were mediated through binding of miR-203 to the presumed sites in the 3′-UTR of the Slug mRNA, the full-length 3′-UTR of Slug was placed downstream of the firefly luciferase gene in a reporter plasmid.

In this instance, nuclear transport is mediated through binding to BARD1, another tumor suppressor that heterodimerizes with BRCA1 to form a complex involved in DNA damage repair [53].

However, all reported functions of chemokines are mediated through binding to their membrane-bound, or occasionally soluble, receptors, and no pathway has been described for intracellular localization of chemokines.