Sentence examples for be mediated through activation from inspiring English sources

Apoptosis induced by c-Myc can be mediated through activation of the ARF-MDM2-p53 pathway, or by activating death receptors, such as CD95/Fas [33].

As there is potential synergy between docetaxel and capecitabine (Nadella et al, 2002), thought to be mediated through activation of thymidine phosphorylase by docetaxel, we also aimed to explore the activity of a doublet regimen, thereby avoiding the potential toxicity of cisplatin.

Taken together, our results show that the DADS analogs induce vasorelaxation and have antihypertensive properties, which may be mediated through activation of eNOS.

In the case of FTY720, its effect on β-cells appears to be mediated through activation of immune cells in the lymph nodes.

It was reported that phosphorylation of FOXO3a could be mediated through activation of the Akt signaling pathway.

Experiments with 8CPT-2'-OMe-cAMP suggested that the delayed effects of ACTH on cortisol synthesis could be mediated through activation of Epac2.

This was mediated through activation of stress-induced mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK), followed by activation of proapoptotic protein Bax, loss of mitochondrial membrane potential, and activation of caspase-3.

Both effects are mediated through activation of H1 receptors.

Prostaglandin E2 (PGE2)–induced tissue remodeling is mediated through activation of prostaglandin E2 receptor type 4 (EP4).

Many studies of chemopreventive drugs have suggested that their beneficial effects on suppression of carcinogenesis and many other chronic diseases are mediated through activation of the transcription factor NFE2-related factor 2 (NRF2).

The fact that DHTS-induced apoptosis could be blocked by pretreating cells with pan-caspase inhibitor confirmed that it is mediated through activation of the caspase-3-dependent pathway.