The non-progesterone-like effect of RU486 may be mediated through a pathway that is different from the progesterone-mediated pathway, or it is the result of a blockade of certain critical step(s) in the progesterone-mediated pathway.
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Moreover, regulation of gene expression does not appear to always be mediated through a single OCR, but on occasion involves a cluster of OCRs.
Moreover, the results suggest that the intracellular role of US might be mediated through a pathway that appears not to be limited to destabilizing the endosomal vesicles.
High-strength static magnetic field stimulation (SMS) results in a period of reduced corticomotor excitability that may be mediated through a decrease in membrane excitability.
Although the mechanisms of sex-related antiretroviral pharmacodynamic differences remain poorly understood and may be multifactorial, they appear to be mediated through a common pathway of pharmacokinetic variability between the sexes.
In addition, we provide parallel evidence that fluoxetine's anxiolytic action may be mediated through a decrease of aversive stimulus- and aversive memory-evoked increases in cholinergic neurotransmission through M1 muscarinic receptors in the hippocampus, although this evidence is strictly circumstantial and needs to be further investigated in future studies.
This association may be mediated through a variable IL-6 expression encoded by the host.
The hypoxic immunomodulatory effects are thought to be mediated through a group of transcription factors called hypoxia-inducible factors (HIFs 2.
PNPLA3-I148M seems to be a loseems-functoon mutation, bet its pathogenic effect appears to be mediated through a gain in function resulting in a suppression of lipase activity.
This indicates that part of the regenerative effect might be mediated through a neovascularization process.
