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Conclusion: The relaxant effects of BRL 37344 appear to be mediated solely through the β3-adrenoreceptor agonist, although ritodrine may exert an effect on β1-, β2-, and β3-adrenoreceptor agonists.
These effects are unlikely to be mediated solely through Vdac1.
Together, these results further emphasize that SWIP behavior may not be mediated solely through dopamine reuptake by DAT-1.
Originally, signaling was thought to be mediated solely through Gα subunits; however, Gβγ complexes are now widely recognized as independent signaling molecules, with effectors such as adenylyl cyclase, phospholipase C-β, PI 3-kinase, and components of the mitogen-activated protein kinase cascade.
A recent study has shown that, in rats, pelvic limb stepping can be mediated solely through propriospinal networks caudal to a spinal cord lesion [ 29], which suggests that evaluation of potentially useful interventions after SCI should also focus on features of the gait apart from simple stepping.
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Although here we exemplified SOCS-3 as a target of miR-203 and showed its down-regulated expression in psoriasis, it is not likely that miR-203 functions in psoriasis are mediated solely through the suppression of this protein.
The assumption that the effects of 5azaC are mediated solely through changes in DNA methylation, however, is not correct.
DCA-induced activation of Fra-1 was dependent on both the Mek1/2-Erk1/2 Mek1/2-Erk1/2and, while JunB activation was mediated solely through the Mek1/2-Erk1/2 cascade in esop38geal cells.
The protein and genomic structure of the present day TACC family members suggests that the function of the ancestral TACC protein was mediated solely through the interactions of the conserved TACC domain.
While CE has become increasingly common in global health research, there is concern that the engagement is often not meaningful, particularly when it is mediated solely through Community Advisory Boards (CABs) [ 10– 10].
However, rather than being mediated solely through pain relief, these improvements may also result from a combined effect on pain and sleep disturbance and a direct effect on patient function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com