Sentence examples for be mediated on a from inspiring English sources

Increased expression and nuclear translocation of SLUG are often correlated with the onset of EMT and our finding provides therefore a possible mechanistic explanation how EMT-associated events in fibrotic areas could be mediated on a transcriptional level.

The effect of comorbidity on mortality may be mediated to a large degree by higher volume of residual tumour.

The association between PCBs and BMI SDS seemed to be mediated by a negative influence on birth weight and length and on length between 1 and 3 years.

Intuitively the chondroprotective effects of calcitonin may in part be mediated through a direct action on chondrocytes and in part through effects on subchondral bone remodeling [ 4].

Vasodilation induced by both derivatives is likely to be mediated by a direct effect on smooth muscle because it was not dependent on the integrity of vascular endothelium.

This effect might be mediated by a direct effect on the brain or by an indirect effect on satiety as a result of the hepatoselective effect of insulin detemir modulating orexigenic and anorexigenic hormones.

The action of caffeine seems to be mediated through a blocking action on adenosine-2 receptors (Schwarzschild et al. 2002).

For example, there is some evidence for the benefit of angiotensin-converting enzyme inhibitors in improving physical function which may be mediated through a direct effect on muscle, and a number of studies are currently underway in this area [ 45].

Here, we thus hypothesize that the effect of NPAS2 rs2305160 on seasonality may, at least in part, be mediated via an influence on testosterone levels.

Moreover, regulation of gene expression does not appear to always be mediated through a single OCR, but on occasion involves a cluster of OCRs.

It is also possible that the in vivo growth inhibition by Hh blockade that we observed might be mediated through an effect on self-renewal property of rare PDAC initiating cells [54].