Sentence examples for be mediated mostly by from inspiring English sources

Therefore the effects previously assigned to T lymphocytes could indeed be mediated mostly by NK cells.

In contrast, PAg recognition may be mediated mostly by germline-encoded CDR loops from Vδ2 and/or Vγ9 chains as PAg-BTN3A1 can be recognised by a wide range of different Vδ2 Vγ9 T cell clones.

Fever production in response to exogenous pyrogens is believed to be mediated mostly by cytokine prostaglandin pathways, and neural input is important in the early phases of fever (9 ).

Most importantly, meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, and this seems to be mediated mostly by subchondral bone changes, suggesting extrusion represents one pathway between bone expansion and cartilage loss.

Although TGF-β effects appear to be mediated mostly by the receptor specific Smad2 and Smad3 proteins [ 47, 48], there is evidence that Smad5 is involved in TGF-β signaling in hematopoietic cells [ 60].

Because the biological effects of 4‑HNE are thought to be mediated mostly by formation of covalent adducts with proteins, a process that frequently alters protein function (reviewed in refs. [ 4, 6- 9]), the observed changes in adduct amounts could be functionally significant.

The specificity of G protein receptor interaction is mediated mostly by the γ-subunit and the individual members of the γ-subunit multigene family would hence be expected to each have a particular expression profile.

G1/S arrest is mediated mostly by the p21 protein whose expression is induced by p53.

VRK2A effects are mediated mostly by its interactions with scaffold proteins that affect cellular signaling.

Therefore, FAD-induced cancer cell death is mediated mostly by caspase-dependent apoptosis.

Data suggests that pruritic responses are mediated mostly by B2 receptors.