Sentence examples for be mediated in large from inspiring English sources
Our data suggest that the long noted cross-regulation of Atoh1 expression by Neurog1 might actually be mediated in large part by Neurod1.
Association of SUR to Kir6.2 is known to be mediated in large part by its N-terminal transmembrane domain TMD0, a ∼200-residue alpha-helical region that binds to Kir6.2 by itself and can promote its targeting to the surface membrane[11].
Proangiogenic properties of HO-1 appear to be mediated in large part by CO through the stimulation of soluble guanylate cyclase in endothelial cells (ECs).
Moreover, these concentrations of the NO donors prevented reperfusion-induced mucosal injury, which has been shown to be mediated in large part by reactive oxygen metabolites [ 27].
Such genetic effects are expected to be mediated in large part via conditionally adaptive responses to environmental variation, which involve epigenetic alterations that modify gene expression and developmental phenotypes (e.g. Bruce and Hanson 2010).
The affinity of Aβ for metal ions is thought to be mediated in large part by imidazole nitrogens of the three N-terminal histidine residues (Nair et al., 2010; Viles, 2012).
The caspase-mediated apoptosis induction by PGG was mediated in large part by activation of p53 as established through siRNA (small interference RNA) knockdown and dominant negative mutant approaches [ 7].
The interactions between the infective organisms and their hosts are mediated in large part by secreted proteins, known collectively as the "secretome".
The interaction between these receptors and G proteins is mediated in large part by the third intracellular loop of the receptor.
In conclusion, our results demonstrate the cardioprotective effect of HBOC on I/R heart and reveal that this protection was mediated in large part by attenuation of mitochondrial oxidative damage.
HSV-1 attachment, followed by fusion and entry, is mediated in large part by the binding of viral surface glycoproteins to cell surface receptors, primarily through heparan sulfate (HS) glycosaminoglycan residues.
