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Such regulation could be mediated for example by squelching of a BPTF transcriptional repressor (as in dominant negative mechanisms) by the miscoded BPTF.
The exact mechanisms by which the IL-17A response contributes to host protection against LVS is still unclear, but could be mediated, for example, by neutrophil recruitment or induction of inflammatory cytokines such as IL-6, GM-CSF and TNFα [45] [46].
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Genomic proximity is known to enhance coordinated expression [52], [53], which is mediated, for example, by local chromatin folding.
These effects are mediated, for example, by hypoxic regulation of cytokine release [ 25] and regulation of tumor suppressors and oncogenes [ 26].
Thus, it is possible that Vpr may facilitate degradation of a specific subset of target proteins by first engaging the VprBP-associated E3 ligase for protein tagging with Ub; the ultimate protein degradation might be mediated by Vpr, for example, through shuttling of ubiquitinated proteins to proteasome via hHR23A.
As the majority of cell sheddase activity is reported to be mediated by metalloproteinases (for example, ADAMs and matrix metalloproteinases (MMPs)), we decided to use chemical inhibitors to examine if cadherin-11 cleavage is mediated by metalloproteinase activity (Fig. 5d).
In general, intestinal epithelial cells are hyporesponsive towards bacterial sensing which is mediated by, for example, the single Ig IL-1-related receptor, inhibiting IL-1 signaling.
Both associations with back pain, the one for BMI and the one for gender, are likely to be mediated by various factors, for example, lack of physical exercise, diet, or genetics.
The same effect would apply for any other interaction which would be mediated by confined bosons; for example, it would also apply to phonon-mediated interactions between electrons or holes.
This can to some extent be mediated by density-compensation for example reduced competition for food, but not entirely.
Considering that these sequences exhibit very high identity (more than 95%), this recombination phenomenon may be mediated by other processes, for example, variation in spatial rate and/or heterotachy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com