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This process can be mediated either through receptor-ligand interactions or through internalization by recipient cells via endocytosis.
This role might be mediated either through an indirect influence on the host immune response or through a more direct influence on the epithelial tumor cell.
This interaction may be mediated either through direct binding to TERT or the RNA subunit of telomerase [34,41] (D. Shippen, personal communication).
This is proposed to occur though dimerization, which could be mediated either through homotypic interactions between the BIR1 domains [ 32] or heterotypic interactions involving both the BIR domains and the C-terminal portion of MALT1 [ 33].
The link between the opening of Ca2+ stores and L-VDCC could be mediated either through the elevation of intracellular Ca2+ [Ca2+] i levels or might involve other mechanisms such as opening of Cl− channels or closure of K+ channels [ 1– 3].
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Copper manipulations were mediated either by increased copper entry, through over-expression of the plasma membrane transporter Ctr1A, or by misregulation of cytoplasmic copper trafficking through loss-of-function mutations of the Atox1 and FKBP52 genes.
Hence, this phenotype is mediated either cell autonomously by daf-16 in the intestine or through daf-16-to-other signaling.
There is some evidence suggesting that deprenyl has cytoprotective and antiapoptotic properties [19], [20], [21], effects that are possibly mediated either through an adaptive increase in superoxide dismutase activity [22], [23] or increased cell-cell adhesion [24].
This indicated that aTRE activity in 100 nM T3 can be mediated through either TRα and TRβ.
The function of AR can be mediated through either receptor-dependent or ligand-dependent pathways.
41 Whether this is stronger in those whose mother had severe HTN during pregnancy requires investigation as the impact of maternal hypertensive pregnancy on offspring risk could be mediated through either a unique familial predisposition or the in utero environment.
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