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We envision that spreading-incompetent (closed) Swi6 dimers is an important factor in counteracting the spread of heterochromatin into the repeat proximal regions, which can be mediated either by the open conformation of Swi6 dimers or by RNAi-mediated H3K9me2 deposition.
The effect of earthworms on the distribution of H. nitidus can be mediated either by direct contact or by odour perception.
Such interaction could be mediated either by a diffusible signal or by cell-cell contact.
This regulation could be mediated either by phosphorylation of the GLI3 molecule itself (which would predict a different phosphorylation pattern of nuclear and cytosolic GLI3) or by phosphorylation of one of its interaction partners.
Endogenous TCR expression in the 5CC7 RAG-2-deficient mice could be mediated either by RAG-dependent recombination [13], gene conversion [14] or gene replacement [15] mechanisms involved in the generation of BCR and TCR diversity.
This effect may be mediated either by LP-induced release of anti-inflammatory mediator/s by ECs, or by some component of L. paracasei that is translocated across the monolayer.
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Tetracycline resistance in GAS is mediated either by tet(M) or tet(O), genes which encode proteins that protect the ribosome [67].
Copper manipulations were mediated either by increased copper entry, through over-expression of the plasma membrane transporter Ctr1A, or by misregulation of cytoplasmic copper trafficking through loss-of-function mutations of the Atox1 and FKBP52 genes.
Having demonstrated that the incomplete PTS of B. melitensis is functional and knowing that PTS-dependent regulations are mediated either by allosteric interaction or by direct phosphorylation of target proteins [1], we performed a Y2H screen to detect interaction partners of the EIIAMan-like protein and NPr of B. melitensis 16M to get some preliminary clues about the functional role of this PTS.
Glucose transport in humans is mediated either by active sodium glucose co-transporters or by facilitative glucose transporters (GLUTs) (15).
Theoretically, the denitrosylation of target proteins is mediated either by catalyzing the conversion of reduced Trx- SH 2 Trx- SH 2ed tox-S2 oxidizedH.
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