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Therefore, beneficial and anti-inflammatory effects of SFN might be mediated by various pathways including modulation of Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF) signaling pathway of TLRs.
Nevertheless, some other studies suggested that this association might be mediated by various confounders (such as poor health status, obesity and lifestyle).
Our hypothesis based on this work and data reported in the literature [7] is that the trans dominant effects of the expanded RNA may be mediated by various factors among which some must be relevant to the pathway of the RNA in which the expansion resides.
These associations may be mediated by various interrelationships among hormones, sexual maturation, and body fat.
The pathogenesis of RA is complex and thought to be mediated by various mechanisms.
These changes may be mediated by various factors such as tumor burden, changes in malignant cell metabolism, tumor necrosis.
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CCR is mediated by various mechanisms, including transcriptional repression and protein-protein interaction-mediated inhibition of substrate uptake- and catabolism related proteins [ 5, 6].
The regeneration of damaged periodontal tissues is mediated by various periodontal cells and is regulated by a vast array of extracellular matrix informational molecules that induce both selective and nonselective responses in different cell lineages and their precursors.
Its enzymatic activity is mediated by various signals, and it acts as a sensor of cellular NADP+ levels (Fig. 3).
The actions of extracellular nucleotides are mediated by various subtypes of ionotropic P2X (P2X1-7) and metabotropic P2Y (P2Y2, P2Y4, P2Y6, P2Y11 P2Y12, P2Y13, P2Y14, P2Y14) receptors.
The wound healing process is mediated by various intracellular, autocrine, and paracrine pathways initiated following pathogen infection or exposure to chemical toxins or other stimuli that induce tissue damage [65-74] [65-74]
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