The overall implication is that cleavage specificity is mediated by sequence-dependent DNA deformations that influence the scissile phosphate positioning and reactivity.
(These results are shown in Figure S5) Thus, rescue is not simply due to expression of an exogenous gene; it is mediated by sequence-specific features of Syn-IlvA-1.
In addition, we have recently shown that the regulatory specificity of a myoblast homeodomain TF is mediated by sequences preferentially bound by that particular homeodomain and not by other related family members (Busser et al., 2012b).
Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements, where BRE, TATA, INR, DPE and MTE motifs constitute canonical core motifs for basal transcription initiation of genes.
We examined whether the interaction between NIPA1 and BMPRII is mediated by sequences on the cytoplasmic tail of BMPRII by transfecting full-length myc-BMPRII or myc-BMPRIIΔtail (Fig. 3G) into HeLa cells stably expressing NIPA1-GFP, and then immunoprecipitating as described earlier.
Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.
We postulated that transcriptional control of var genes may be mediated by unknown sequence information contained within the promoter region.
Genome diversity in M. avium subspecies appears to be mediated by large sequence polymorphisms that are commonly associated with mobile genetic elements.
The study confirmed that genome-wide DNA methylation is highly tissue-specific; however, the authors also noted a striking similarity between DNA methylation differences in the blood and brain (cerebellum and cortex) from the same individual, prompting the hypothesis that between-individual DNA methylation differences may be mediated by DNA sequence variation, which does not vary across tissues.
Rather the nuclear uptake is likely to be mediated by specific sequences or domains within ARTD10 such as an NLS [ 16].
