Sentence examples for be mediated by reduction from inspiring English sources
The mechanism of action of [d-Ala2]-GIP appeared to be mediated by reduction in intracellular calcium concentration and oscillation that subsequently inhibited calcineurin activity and NFATc1 nuclear translocation.
Pleiotropic effects of statins are thought to be mediated by reduction in the isoprenylation of many proteins.
Thus, the high response rate in the clinical phase II study may be mediated by reduction of doxorubicin-induced NF- κB activation.
This effect is thought to be mediated by reduction in insulin resistance and metabolic syndrome components demonstrated in patients treated with TNF blockade [ 18- 22].
Interestingly, add-on oral pranlukast was found to significantly reduce the levels of alveolar nitric oxide, a parameter of small airway inflammation, suggesting that the additional clinical effect of oral pranlukast could be mediated by reduction in peripheral airway inflammation.
Improved clinical outcomes may be mediated by reduction in the extracellular fluid volume and improved blood pressure control, enhanced clearance of uremic toxins, or more consistent mineral metabolic control [ 11- 13].
Furthermore, ASB requires performing a two-step reaction in order to couple the ligand to the cross-linker, and biotin transfer from ligand to receptor is mediated by reduction of a disulfide bond, making its application sensitive to reductive environments.
Further, the Western blotting showed apoptosis was mediated by reduction in ratio of Bcl-2 and Bax protein expression, and activation of caspase-3 through release of cytochrome-c in DL cells.
The indirect benefit of circumcision interventions to women (and uncircumcised men) is mediated by reduction in HIV prevalence among their circumcised male sexual partners (and partners' partners).
Several studies have shown that the anti-inflammatory activity of embelin is mediated by reduction in TNF-α.
