Sentence examples for be mediated by modulating from inspiring English sources

Our results revealed that antidepressant-like effects of rolipram in OBX model may be mediated by modulating the hypothalamic pituitary adrenal (HPA) axis activity, increasing the cAMP signaling aspects and restoring the antioxidant mechanisms.

Based on these observations we hypothesised that the OA association to COL11A1, marked by rs2615977, may be mediated by modulating the expression of the gene in articular cartilage.

Furthermore, considering the preferential targeting of Bcl-Xl to the mitochondrial outer membrane, we speculate that the protective action of BH4-Bcl-Xl may be mediated by modulating mitochondrial targets.

Although it seems likely that the effect of sodium butyrate on LP BER is mediated at least in part by increased acetylation of WRN, it remains possible that the effect of sodium butyrate is mediated by modulating the interaction between WRN and other proteins involved in BER.

These results indicate that negative regulation of chondrogenesis by the over-expression of PRTG is mediated by modulating apoptotic death of chondrogenic competent cells.

We previously showed that NDRG1 blocked metastasis in an animal model and that this suppressor effect is mediated by modulating ATF3, which functions as a strong pro-metastatic transcription factor (Bandyopadhyay et al, 2006a, b).

Taken together, our data indicate that the primary effect of Fj on wing size is mediated by modulating the steepness of the Ft-Ds-binding gradient, with a smaller contribution attributable to the effect of Fj on overall strength of Ft-Ds binding.

More recently, EGF-induced internalization of E-cadherin-catenin complex was suggested to be mediated by Rac-modulated macropinocytosis [49].

The effects of inflammation on mood and behaviour could partially be mediated by kynurenine pathway metabolites, modulating neuroinflammation and glutamate neurotransmission.

This tamoxifen resistance is overcome by HER-2 kinase inhibitors (Lu et al, 2011), suggesting that EBP1's effect on tamoxifen sensitivity may be mediated by its ability to modulate ErbB2 expression.

Since the effects associated with bupivacaine are at least in part believed to be mediated by signals with potential to modulate S6K activity, we attempted to investigate such a possibility for further insights into the antiproliferative effects of the anaesthetic and relate it with inhibition of S6K pathway.