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These effects seem to be mediated by modifications to cell-matrix interactions between MSCs and the CDM; however, further work is necessary to elucidate the specific mechanisms involved in this process.
These effects on offspring are thought to be mediated by modifications of glucocorticoid and androgen plasmatic concentrations in pregnant females [13], [16], [17].
As we discuss below, these neuroprotective effects of lithium could be mediated by modifications of the plaque toxicity through the astrocytic release of heat shock proteins.
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These results suggest that the mechanism of drug sensitivity modification by flunarizine is not related to modification of tumour blood flow, but may be mediated by modification of transport mechanisms that are differentially responsible for cellular uptake and retention of melphalan as compared with cyclophosphamide.
Conversely, resistance to gentamicin is mediated by modifications at few sites on the molecule.
It is conceivable that the plethora of observed actions of Ang1 on permeability coefficients are mediated by modification of a variety of different ultrastructural features of different microvascular beds that result in parallel changes in permeability coefficients.
An intermediate response to alter the proteome is mediated by modification of the transcripts recruited to the ribosomes and allows for fast adjustment of de novo synthesized proteins [ 2].
Recent studies have suggested that the involvement of sialyltransferase and fucosyltransferases (FUTs) on cancer progression such as cancer cell metastasis and invasion are mediated by modification of the cell surface by these enzymes to attachment of glycosyl residues (Park et al, 2012).
Beyond allelic differences, which can be mapped with QTL-analysis, welfare related biological responses may be mediated by acquired modifications in expression levels of genes and gene complexes.
Such effects across three generations are also assumed to be mediated by epigenetic modifications [ 37– 37].
This activation appeared not to be mediated by oxidative modifications of the enzyme.
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