All of these effects are thought to be mediated by increased activation of serotonin receptors throughout the brain regions involved.
The present study was designed to investigate whether DOI-induced renal vasodilation might be mediated by increased nitric oxide (NO) release/production in renal tissue.
The link between upward career transitions and career satisfaction could be shown to be mediated by increased person job fit, but not by autonomy.
Apoptosis in these cases were hypothesized to be mediated by increased oxidative stress in the cells.
In fact, the bacterial loads in these groups were similar to groups where macrophages were conditioned with recombinant IFN-γ prior to BCG infection, indicating that enhanced killing could be mediated by increased secretion of IFN-γ by T cells.
Interestingly, in cultured neural cells, chronic ethanol exposure increases levels of PKCδ or ε [35], suggesting that increased uptake activity of ENT1-216Thr in response to chronic ethanol exposure, in part, could be mediated by increased PKCδ or ε activity.
This increase in SWS over time is thought to be mediated by increased adenosine release and accumulation over extended waking periods, resulting in greater slow-wave activity at sleep-onset [46] [49].
We propose that maternal UN, particularly at a time-point that includes pregnancy, results in reduced offspring ovarian follicle numbers and mRNA levels of regulatory genes and may be mediated by increased ovarian oxidative stress coupled with a decreased ability to repair the resultant oxidative damage.
These effects are thought to be mediated by increased activation of MGP (10).
This appears to be mediated by increased oxidative stress and persistently activated CaMKII.
We thus suggest that the increased apoptosis in Koltho may be mediated by increased actASK1-signalosome activity.
