Sentence examples for be mediated by direct from inspiring English sources

Mechanistically, this could be mediated by direct binding of NF-κB to the promoter of cell-cycle mediators, as it has been shown to transcriptionally regulate cyclin d1[ 38].

The effects of ecosystem engineers can be mediated by direct and indirect interactions.

HNF-4 and ARP-1 bind with similar affinities to the C3P site, suggesting that their opposing transcriptional effects may be mediated by direct competition for DNA binding.

While it is clear that hypothalamic Y4 receptors (i.e. in the ARC) are required for PP-induced neuronal activation and stimulation of POMC mRNA expression, this effect could be mediated by direct and / or indirect effects on POMC neurons.

Unlike our compounds, however, inhibition of Stat3 by Stattic was blocked by addition of a reducing agent (dithiothreitol, DTT), was not reversible, and may not be mediated by direct inhibition of pY-peptide binding.

While the reduced inhibitory effect of the C3-diastereomer, epi-cholesterol, on KirBac1.1 activity is suggestive that cholesterol inhibition may be mediated by direct interactions [8], [21], epi-cholesterol and cholesterol orient differently in membranes and may alter membrane properties differently [22], [23].

Unconventional secretion of FGF2 from cells is mediated by direct protein translocation across the plasma membrane.

It is currently not clear whether CNOT2 (or CNOT1 and CNOT3) are associated with the DNA or chromatin and whether this is mediated by direct or indirect effects.

We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo).

While conducting downstream targeting studies, we found that the tumor-promoting function of miR-4516, in part, was mediated by direct targeting of PTPN14 (protein tyrosine phosphatase, non-receptor type 14) which, in turn, regulated the Hippo pathway in GBM.

The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cells are transferred to B6 IL-1R1−/− recipients and only cells that express IL-1 receptors can respond.