Sentence examples for be mediated by blocking from inspiring English sources
Its antiparkinsonian effect is thought to be mediated by blocking the well-known adenosine A2A receptor (A2AR -mediated tonic inhibition of dopA2AR -mediatedtonicD2R) sinhibitionn the striatofallidopamineway.
However, Wang et al. showed that protective effects of octacosanol against Parkinson might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction24, more work needs to be done to understand its mechanism of action.
Chimeric protein fusions of Wnt isoforms with LRP6, but not FZD, are insensitive to inhibition by the LRP6 antibodies, suggesting that antagonism may be mediated by blocking ligand-coreceptor interactions.
This effect may be mediated by blocking tyrosine kinases other than BCR-ABL, such as c-KIT or SRC; hence, the precise mechanism needs to be addressed further.
Furthermore, IL-1β inhibits Smad4 in a chondrocytic cell line (SW1353), indicating that the antagonistic effect of IL-1β on TGF-β may be mediated by blocking the expression of Smad4 [ 36].
Given that the activities of Flt-1 and its downstream target pAkt are critical to VEGF165 signaling for chemotaxis [ 53, 54], the anti-migratory action of sFasL may be mediated by blocking VEGF165-induced upregulation of pAkt activity.
This led to an enhanced TGF-β1 response and interfered with the ability of AZD8055 to inhibit TGF-β1 induced collagen synthesis (Fig. 6a, b) indicating that the inhibitory effects of AZD8055 are mediated by blocking the phosphorylation of 4E-BP1.
Apparently, vasodilation is mediated by blocking calcium influx and competitive inhibition of calcium binding [ 65].
Moreover, the inhibition of TNF-α and IL-1β by DE is mediated by blocking NF-κB activation in RAW 264.7 cells.
Second, the suppression of HBV replication by CsA reported previously was mediated by blocking the mitochondrial permeability transition pore possibly through binding to mitochondrial CyPD.
The inhibitory effects of SOCS1 were mediated by blocking p38, c-Jun N-terminal kinase (JNK), and nuclear factor κB (NF-κB) activation, and by downregulating transforming growth factor-β-activated kinase 1 (TAK1) expression.
