Sentence examples for be mediated by binding from inspiring English sources

This may be due to secondary transcriptional effects, which could be mediated by binding of HuR to the mRNAs encoding transcription factors that regulate EphA2 expression.

Given the association between SARs and transcription (Fig. 3), recruitment to the nuclear scaffold may also be mediated by binding of transcription factors at promoters and long distance cis-elements such as enhancers and locus control regions.

In addition, MGP effects on glioblastoma cell migration might be mediated by binding of MGP to vitronectin [ 31].

APP endocytosis is known to be mediated by binding to the low-density lipoprotein receptor-related protein-1 (LRP1).

NLG-1 association with UNC-49 could be mediated by binding to an intermediary Gephyrin-like molecule.

The direct effect of vitamin D may be mediated by binding of its circulating active form 1,25- OH 2D3 to the beta cell vitamin D receptor.

We conclude that UBX proteins are transcriptional repressors and activators, and that their actions are mediated by binding to promoter region sequences.

These results suggest that the regulatory activities of Ubx are direct and are mediated by binding of Ubx proteins to promoter region sequences.

The interaction with lipids and calcium activators is mediated by binding to the regulatory domains C1 and C2.

Structurally, this interaction is mediated by binding of the α-helical BH3 region of the proapoptotic proteins to a conserved hydrophobic groove on the prosurvival proteins.

Subsequent studies provided a structural basis for selective m6A binding (14) and showed that the destabilizing effect of m6A is mediated by binding to a family member, YTHDF2 (15).