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In conclusion, while we cannot exclude the possibility that the effect of the two antagonists on c-fos expression could also be mediated by additional targets, a significant effect seems unlikely given the higher specificity of the compounds against the TRPV1 channel and the TRPV1-specific block observed in the CGRP experiments.
Some self-interactions also appear to be mediated by additional sites: all the partial fragments of VP19, VP28 and VP51A were shown to interact with their own full length proteins, which implies that the monomers of these proteins might interact via several sites to form the oligomers.
Likewise, associations between inflammatory biomarker levels and QoL may themselves be mediated by additional social factors.
Therefore, whereas the effects of ND on differentiation are mediated by mTOR, its effects on proliferation are likely to be mediated by additional cellular mechanisms.
We also evaluated the extent to which these associations may be mediated by additional spatially correlated factors related to the built environment (air pollution, noise, walkability of residential neighborhoods, and access to parks) to help elucidate potential pathways of influence.
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Our novel results suggest this promoter specificity is mediated by additional unknown cis-regulatory elements present in the native promoters that are required for the recruitment of Mam and formation of functional Su(H /NICD/Mam complexes on SPS elements.
Thus the transcriptional regulation by NFIX is mediated by additional mechanisms other than the known NFI-binding sites.
Because no statistical increase in Ac-LDL uptake was observed for CD34+ cells cultured in EC-conditioned medium, the endothelial differentiation of CD34+ cells is mediated by additional factors to the ones secreted by the CD34+-derived ECs.
These data supported the conclusion that the initial increase in [Ca2+]i was mediated by NMDAR stimulation, whereas the following DCD was mediated by additional sources of Ca2+.
Directionality of transport is mediated by additional soluble factors found at the NPC faces, or in the nucleus or cytoplasm (reviewed in Kabachinski and Schwartz 2015).
It is also possible that the expression of male killing is mediated by additional factors, such as changes in the tropism or level of expression of genes that are also present in non-male-killing strains of Wolbachia.
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