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Additional outcomes to be collected every 6 months will include: 1. Household income and employment status 2. Quality of life and utility measurement: Health related quality of life will be measured using validated, widely-used instruments.
To capture the severity and impact of fatigue appropriately it must be measured using validated scales.
Subjective ratings of appetite will be measured using validated visual analogue scales (VAS) by the subjects at home on a weekly basis.
Additionally, the effect of the drug in children should be measured using validated age-appropriate endpoints, which may vary between the youngest children versus older children and adults.
Self-efficacy can be measured using validated scales specific to the behaviours and activities at which an intervention aims to influence [ 26- 28].
As stated above, it is recommended plasma glucose levels be measured using validated methodology and that SUL be calculated with and without plasma glucose correction in all response monitoring studies.
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Leadership role perspectives and conflict resolution styles were measured using validated scales constructed by us based on the literature review, interviews and expert opinion.
Germane cognitive load was measured using validated a self-reported cognitive load subjective rating scale.
Variables were measured using validated questionnaires.
Adipose tissue thickness was measured using validated standardized criteria [ 68].
SBWC was measured using validated methods that have been previously described (20).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com