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Social contacts will be measured using three dimensions of the MATE (Measurements in the Addictions for Triage and Evaluation) part 7 'Activities & Participation, Care & Support': (1) interpersonal interactions and relationships, (2) important areas of life, and (3) social life [ 74, 75].
The ick factor will be measured using three items (e.g. "The thought of organ donation makes me uncomfortable").
Sleep quality will be measured using three validated self-report measures (the Pittsburgh Sleep Quality Index [ 31] the Insomnia Severity Index [ 32] and the Pittsburgh Sleep Diary [ 54] and a validated objective measure, the Actiwatch [ 30].
Perceived behavioral control will be measured using three items (e.g. "How confident are you that you can keep your alcohol drinking to within safe limits on each individual occasion or session over the next four weeks?") on six-point Likert-type scales ranging from 1 (no control at all) to 6 (complete control).
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The distance between two markers on a chromosome can be measured using (one of a number of) genetic techniques.
Knowledge will be measured using seven multiple choice items, with two to four answer options.
At 3 and 12 months, outcomes will be measured using four behaviour specific questionnaires.
Social influence will be measured using two different concepts: social norms and modelling.
Exposure to abuse through the lifespan will be measured using two psychological instruments.
HRQoL will be measured using two questionnaires, the EQ-5D and the EORTC QLQ-30.
Job satisfaction will be measured using two subscales of the Leiden quality of work questionnaire [ 34].
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