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This study suggests that the actual cells responsible for drug resistance may be masked when analyzing large sections of the primary carcinoma, but single-cell RNA-seq data may be useful for detecting rare potentially drug-resistant sub-clones.
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In this way, the eventual biogeographic patterns due to vicariance events that can be observed in certain taxa, can be masked when trying to analyze spatial patterns for the whole group of mollusks.
Nevertheless, this observation is at odds with the description of cancer stem cells as a minority population within a tumor, because the gene expression profile of these rare cells is likely to be masked when tumors as a whole are analyzed for gene expression [36].
Some relationships can be masked when using wider aggregations such as monthly data (Eisenberg 2004).
Differences in particular organ(s) might have been masked when whole fly bodies were analyzed.
However, the differences attributable to interfacial chemistry are masked when highly viscous liquids are used.
Notably, these kinds of relationships are masked when using traditional linear statistical approaches.
Fluctuations in single cells can be masked or completely misrepresented when cell populations are analyzed.
Such effects would be masked in tissue culture experiments where isolated adiopocytes are analyzed.
The whir of the fan was masked handsomely when I put the headphones on.
The primary investigator was masked to patient's identity and procedures when analyzing the MEI results (pre and post intervention) of all patients.
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