Nevertheless, this in vivo toxicity can be markedly reduced either through the administration of human recombinant IL-2, or liposome encapsulation [ 228, 229, 231].
Basal SFK activity was found to be markedly reduced in CD148-deficient platelets, resulting in a global hyporesponsiveness to agonists that signal through SFKs, including collagen and fibrinogen.
When differential quantization is employed, utilizing the APCDQ algorithm, the performance loss can be markedly reduced.
Therefore, in the interest of having more economic return, pigging frequency must be markedly reduced.
Through prevention and early treatment of T2DM, the time spent in the more severe and costly states can be markedly reduced.
Immediately after laser irradiation, epineurial vessels were occluded due to the formation of thrombi, and the blood flow through these vessels was markedly reduced.
In addition, stimulation of insulin secretion by GIP is markedly reduced in hyperglycaemic type 2 diabetes patients through a defect in β-cell sensitivity to GIP 12. Therefore, DPP-IV inhibitors and long-acting GLP-1 analogues have emerged as a new class of anti-hyperglycaemic drugs.
Notably, C3a-C3aR engagement was markedly reduced in rhDAF-treated BOP injured animals, presumably through limiting local expression of C3aR and C3a and/or preventing the extravasation of systemic C3a through increased integrity of the BBB.
In particular, mobility and mental well-being were reduced; moreover, quality of life was markedly reduced.
