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Menadione redox cycling by purified rat liver TrxR was found to be markedly less sensitive to NAPQI when compared to the disulfide reduction (IC50 = 0.980 ± 0.063 vs 0.023 ± 0.001 μM for the generation of H2O2 production during redox cycling and disulfide reduction, respectively) (compare Figures 4A and 7D).
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ICaL carried by α1c-D was markedly less sensitive to nitrendipine (IC50 17.1 μM) than α1c-wt (IC50 88 nM); a feature exploited to discriminate between engineered and native currents in transduced guinea-pig myocytes.
The instrumental role of SphK1 inhibition in reduced cell growth was confirmed by cell viability assays, which showed that LNCaP overexpressing SphK1 were markedly less sensitive to the effects of androgen depletion (Fig. 3B).
Thymus-derived Tregs are markedly less sensitive than effector T cells to oxidant stress induced cell death [36] and this perhaps suggests a particular role for ROS in Treg function and physiology.
We found that menadione redox cycling by TrxR was markedly less sensitive to NAPQI than disulfide reduction, suggesting that TrxR mediates these reactions via distinct mechanisms.
does the impact of SE vary differentially with genotype at G?—inferences are markedly less sensitive to conventional confounding as described above.
As shown in Figure 6f, a clone displaying overexpression of ezrin was markedly less sensitive to UA-induced apoptosis than control cells (P<0.01).
As expected, the lymphoma cells derived from the TCL1-Tg:p53R172H/R172H mice were markedly less sensitive to Nutlin-3a than those derived from the TCL1-Tg:p53WT/WT mice (Fig. 2d).
But some things seem to be markedly less genetic.
Japan's newspapers fear that there will be markedly less communication between journalists and government officials.
EM-2 cell line was most sensitive to cytotoxic drugs, whereas K562 and MOLM-1 were markedly less so.
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